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Perhaps future research will conclusively demonstrate a role for N-acetylcysteine in the treatment of mental illness and athletic performance, but for now it is only in acetaminophen overdose that that the use of NAC is well established
Interestingly, in addition to proper supplementation support, another recommended treatment for cerebral folate deficiency is a dairy-free diet (something I advocate for in Hashimotos too), as mammalian milk is thought to contribute to folate receptor antibodies, and may block folate transport to the brain
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Maritim A, Dene BA, Sanders RA, Watkins JB
This is why combining the two pathways produces additive effects