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Stomach acid and a protein called intrinsic factor (IF) aid in B12 absorption
The key principle is achieving gradual, sustained weight loss rather than rapid reduction
Clinical trial data from the STEP 1 and SURMOUNT-1 trials show that patients typically achieve 1015% total body weight loss with semaglutide 2.4 mg weekly (Wegovy) and 1520% with tirzepatide 1015 mg weekly (Zepbound) over 1218 months
But the biological plausibility is sound, and some clinicians are incorporating this strategy into their long-term GLP-1 treatment plans
Semaglutide with B12 and semaglutide with methylcobalamin are popular options that combine the GLP-1 receptor agonist with vitamin supplementation
These hormonal shifts may occur through: Direct effects on hormone production Changes in body composition from weight loss Alterations in insulin sensitivity Potential Cause #2: Brain Reward System Effects Ozempic works by targeting areas of the brain that control both appetite and pleasure responses
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