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The most frequent were nausea, diarrhea, and anorexia

Common side effects may include: Mounjaros side effect profile is better established because it is licensed

Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis

In a 26-week study, patients treated with tirzepatide experienced dose-dependent decreases in HbA1c of up to 2.4%, while those treated with dulaglutide reported reductions of up to 1.1% [11]

So far, the literature hasn't raised major alarms, but the data is still nascent

In the meantime, Mounjaro at 22.5% average weight loss remains the strongest licensed option available and produces results that, until recently, would also have seemed impossible. TRIUMPH-1 Extension: Results to 104 Weeks A pre-specified blinded extension of TRIUMPH-1 followed 532 participants with a baseline BMI of 35 or higher who completed the main 80-week study