In a 15-year follow-up of 266 elderly patients treated with epithalamin (the precursor compound), Khavinson and colleagues reported a 28% reduction in cardiovascular mortality in the treatment group compared to controls 4
A 26-Week randomized controlled trial of semaglutide once daily versus liraglutide and placebo in patients with type 2 diabetes suboptimally controlled on diet and exercise with or without metformin
Safety of treatment, changes in risk factors, and incidence of coronary heart disease
GIP, another incretin hormone, also plays a role in insulin secretion and glucose regulation, and its combination with GLP-1 has shown enhanced weight loss effects
Other gastrointestinal effects that may occur on the first day or within the initial week include mild abdominal discomfort, bloating, or changes in bowel habits
Burning or stinging that intensifies rather than diminishes