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Severe gastrointestinal issues: Individuals with a history of severe gastrointestinal problems, such as gastroparesis or pancreatitis, should steer clear of this medication, as semaglutide can exacerbate these conditions

There are, however, some side effects to look out for while you perform your injections

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Some are easier to tolerate on a queasy stomach

the clinical significance in humans remains under investigation and is not yet established for retatrutide specifically [24] [25] Other class-associated cautions: Based on the broader GLP-1/GIP receptor agonist class, potential effects on gallbladder function and delayed gastric emptying are relevant considerations, though evidence specific to retatrutide is still emerging It is important to note that this evidence derives from early-phase trials conducted under controlled conditions with medical supervision

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