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For instance, administration of UroA to Caenorhabditis elegans led to a significant extension of lifespan, while rodent studies showed enhanced muscle endurance and reduced signs of muscle ageing (Reference Ryu, Mouchiroud and Andreux15)

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Experts recommend using the lowest effective of the peptide and initiating research with melanotan 2 at a lower dosage within the range of 0.25-0.5mg/daily

Taken together, these studies demonstrate that alterations in the gut microbiome and its metabolic products are consistently associated with immune dysregulation and symptom severity in CFS/ME, suggesting that targeting the microbiome may offer promising new avenues for diagnosis and treatment