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Managing Side Effects During Tirzepatide Dose Escalation Gastrointestinal effectsincluding nausea, vomiting, and constipationare the most common side effects during tirzepatide titration, occurring in 2540% of patients but typically diminishing after 48 weeks of consistent dosing
Long-term PPI use impairs intestinal magnesium absorption, likely through inhibition of TRPM6/7 magnesium transport channels
Importantly, patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2) should not use semaglutide, as noted in the boxed warning
doi: 10.1073/pnas.1412271111
Their effects on appetite are peripheral
