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Russian clinical trials have contributed valuable data, but methodological differences, including smaller sample sizes, different statistical approaches, and less rigorous blinding procedures compared to FDA standards, mean that Western regulatory agencies generally do not accept this data for drug approval

Furthermore, brain BDNF levels were increased significantly in proportion to the increase in DHA 24

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Prolonged vitamin B12 deficiency can also lead to irreversible damage to the nervous system

Journal of Chromatography B, 1235, 124033