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A 2025 narrative review that searched six databases through March of that year found robust regenerative signals in preclinical work but only three published human clinical trials of BPC-157 and concluded that the compound should still be considered investigational, noting the anti-doping and compounding restrictions that regulators had applied over the lack of human safety data
Servais A, Saitovitch A, Hummel A, Boisgontier J, Scemla A, Sberro-Soussan R, Snanoudj R, Lemaitre H, Legendre C, Pontoizeau C, Antignac C, Anglicheau D, Funalot B, Boddaert N (2020) Central nervous system complications in adult cystinosis patients
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The difference between a BPC-157 protocol that works and one that does not is rarely the peptide itself
The molecule simply doesn't survive digestion intact
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