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Circulating mtDAMPs activate pulmonary neutrophils and endothelial cells, causing increased vascular permeability, alveolar edema, and acute respiratory distress syndrome (ARDS)a major cause of postoperative morbidity and prolonged mechanical ventilation ( Renal injury: Aortic cross-clamping and cardiopulmonary bypass create renal ischemia, leading to tubular mitochondrial damage, mtDAMPs release, and neutrophil-mediated tubular injury
thus, antioxidant therapy has shown efficacy in the treatment of specific conditions
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