In less than a decade, the field has progressed from single-receptor compounds (semaglutide) to dual-receptor compounds (tirzepatide) to the first triple-receptor agonist retatrutide currently in advanced clinical trials
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Varanasi A, Patel P, Makdissi A, Dhindsa S, Chaudhuri A, Dandona P: Clinical use of liraglutide in type 2 diabetes and its effects on cardiovascular risk factors
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Tirzepatide reduced waist size by about 18.4 centimeters, compared with about 13 centimeters for semaglutide