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Medical professionals advise against twice-weekly semaglutide because it bypasses the medication's mechanism of action

The hypothetical estimand (on-treatment without rescue medication) showed a statistically significant difference between the 16 mg and 2 mg groups, for both the HbA1c reduction and a weight loss with -0.5 percentage points (95 % CI: -1.0 to -0.1

Avoid high-caffeine drinks, which increase urine output and may worsen dehydration

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Bone turnover markers: In the simple weight loss group, OC decreased by 20% and CTX increased by 30%