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When B12 levels are low, some people may experience tiredness, weakness, low energy, mouth symptoms, pins and needles, memory changes or other symptoms that affect daily life
The loading phase is extended, with injections given on alternate days until no further improvement is observed, which may take several weeks or months
Any combined use would be highly experimental and should only occur under close medical supervision within appropriate research contexts
Thus, while the additional studies will be done, we could suggest, based on the role of NO-system (Toda and Nakanishitoda, 2007
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