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So the "vs" here is really a comparison between a fat-cell-targeting fragment and gut-hormone-mimicking peptides

(1997, Journal of Endocrinology) reported that IGF-1 LR3 supported protein turnover in tumor-bearing catabolic rats but also increased tumor growth in that model

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The idea is simple: if topical use can improve surface-level markers, deeper systemic exposure may be worth exploring for people who want support that goes beyond what a serum can do on its own

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