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132 DTP cells constitute a transient, nongenetic adaptive state that enables a minor tumor cell subpopulation to survive otherwise lethal anticancer therapies and acts as a critical reservoir for resistance evolution within a dynamic balance between state maintenance and exit trajectories (Fig
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10.1016/j.freeradbiomed.2023.12.022 14 AshokA.AndrabiS
It typically begins between the ages of 45 and 55 and signals the end of a womans reproductive years