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[126] demonstrated in a drug clinical study in 2018 that GLP-/GIP dual agonists could significantly reduce TG and TC levels in patients compared with placebo
In the Phase 2 trial published in the New England Journal of Medicine, participants receiving the highest dose of retatrutide achieved an average body weight reduction of 24.2% over 48 weeks
E.VanceD
Pharmacol Ther 113(3):546593 Dozio E, Vianello E, Malavazos AE, Tacchini L, Schmitz G, Iacobellis G et al (2019) Epicardial adipose tissue GLP-1 receptor is associated with genes involved in fatty acid oxidation and white-to-brown fat differentiation: a target to modulate cardiovascular risk
Compounded versions of semaglutide and tirzepatide are not FDA-approved, and their safety and effectiveness have not been approved by the FDA
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