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doi:10.1021/acs.jmedchem.7b00389
The presence of furin cleavage site in diphtheria toxin (R-V-R-R ) and Pseudomonas exotoxin A (R-Q-P-R ), enhances their cytotoxic spectrum 339,340
FOXO4-DRI is studied in this context
In another study, metabolomic analysis revealed the difference in levels of metabolites related to gut microbiota of mice bearing glioma cells sensitive and non-sensitive to temozolomide [192]
Within minutes of administration, BPC-157 triggers changes in the expression of genes like Akt1, VEGFR2, and eNOS
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