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In addition to PDHC and OGDH(L)C, this action of thiamine is mediated by two other ThDP-dependent multienzyme complexes, i.e., those of branched chain 2-oxo acid dehydrogenase (BCODH) and OADH, functioning in the pathways of degradation of branched-chain -amino acids, and lysine and tryptophan, respectively (Figure 1)
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Research has shown that these nutrients can support mitochondrial function, improve brain function, reduce neurological damage and, in doing so, help support good quality sleep (which means a reduced risk of experiencing sleep apnea)
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Among first-time prescriptions for which use could be established, ADMs accounted for 83.0% and AOMs accounted for 17.0%
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