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These data indicate that GLP-1 regulation of ABCA1 protein levels involves AMPK-dependent inhibition on PARP-1 phosphorylation and PAPR-1 activity

Zhao et al., 2017

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State Coverage Criteria and Prior Authorization Requirements Most states that do cover GLP-1 medications impose strict clinical criteria: documented type 2 diabetes diagnosis, failure on other antidiabetic agents, and often a minimum BMI threshold