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Importantly, BPC 157, but not PDGF-BB, stimulated earlier maturation of granulation tissue, soluble collagen concentration in the exudates (using sponge implantation), and organized collagen significantly more in wounds (i.e., on day 12 after daily treatment) (Tkalcevic et al., 2007)

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The rationale is borrowed from other compounds where tissue saturation and receptor dynamics justify phased dosing

I usually place copper peptides high on the shortlist for pale, established marks that need a more treatment-led formula