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In preclinical data, the pair improves adipocyte NAD+ by inhibiting NNMT, resulting in better fat metabolism and reduced obesity.[8][3] For anti-aging, this translates to improved tissue resilience and reduced senescence
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Pancreatitis and pancreatic cancer were reported in some studies but not in large CVOTs with relatively long duration of follow-up
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To account for clustering within the 1:1 propensity-matched sample and address the loss of independence among individuals resulting from the matching procedure, we incorporated a robust variance estimator in the Cox regression model [21]