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It was found that plasma levels of GLP-1 in mice with signs of AD were reduced and negatively correlated with -amyloid levels in patients with AD
May offer therapeutic effects in Parkinson's disease
In a phase 3, double-blind, randomized, controlled trial, 2,539 adults with a body-mass index (BMI) of 30 or greater, or 27 or greater with at least one weight-related complication, were given weekly subcutaneous injections of tirzepatide (5 mg, 10 mg, or 15 mg) or a placebo for 72 weeks
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Consistently, genetically predicted acetyl-carnitine was also related to higher risk of CAD (OR 1.06, 95% CI 1.01 to 1.10) and heart failure (OR 1.07, 95% CI 1.01 to 1.14) (Additional file 2: Fig
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