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Pinch a fold of skin between your thumb and fingers (this step only applies to abdominal injections
In the SURMOUNT-1 trial (Jastreboff et al., NEJM 2022), adults with obesity (without diabetes) receiving tirzepatide 15 mg weekly achieved a mean weight loss of 20.9% over 72 weeks, compared to 3.1% with placebo
[6] Vukojevi J, et al
These are typically transient and subside over time
S2CID 24945528
But heat seems to be able to do a lot of the same things
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