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For researchers tracking this space, the key trials to watch in 2026 include the remaining TRIUMPH program readouts for retatrutide, the GLORY-OSA trial for mazdutide in obstructive sleep apnea, and the first Phase 1 data from several quadruple-agonist programs entering clinical development
Holman RR, Bethel MA, Chan JC, Chiasson JL, Doran Z, Ge J, Gerstein H, Huo Y, McMurray JJ, Ryden L, Liyanage W, Schrder S, Tendera M, Theodorakis MJ, Tuomilehto J, Yang W, Hu D, Pan C, ACE Study Group
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Retatrutide (LY-3437943) is a synthetic 39-amino-acid peptide developed as a triple agonist of the GLP-1, GIP and glucagon receptors
Mechanism of Action 2,3 Glucagon-like peptide-1 (GLP-1) is a hormone produced and secreted in intestinal cells and in the brainstem upon food consumption
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