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137 The ECM not only provides physical scaffolding but also functions as a biochemical regulator of resistance

A 35-day Chronic Unpredictable Mild Stress (CUMS) protocol was implemented (detailed in Figure S2) 40,41,42,43,44 , involving 33 male Wistar rats divided into a non-stressed control group receiving saline (NaCl 0.9%, 1.5 ml) (Control + Saline, n = 9) and two CUMS-exposed groups receiving daily intraperitoneal injections of either saline (CUMS + Saline, n = 9) or 10 mg/kg fluoxetine (CUMS + Fluoxetine, n = 15

Oxidative stress-mediated beta cell death and dysfunction as a target for diabetes management

Yin et al., 2016)

Have symptoms fluctuated over time

J Neuroendocrinol