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The study found that GLP-1 receptor activation reduces inflammation and oxidative stress in liver tissue exposed to alcohol

Specifically, the decrease in SIRT1 levels, inhibition of its activity, or generation of mutations that lower its activity have been linked to intestinal inflammation and colitis in human and rodent models (Wellman et al., 2017)

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However, the risk increases when combined with other diabetes medications, particularly insulin or sulfonylureas, and this risk could theoretically be compounded by adding berberine