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Step 7: Hold for 10 seconds

GLP-1 drugs may be prescribed for the following conditions as per American Diabetes Association/European Association for the Study of Diabetes (ADA/EASD) 2025 guidelines 11 : Primary glycaemic indication: GLP-1 RAs are recommended for adults with type 2 diabetes who have not reached their individualised A1C targets (typically when A1C is 1.5% above the agreed glycaemic goal) despite lifestyle measures and foundational therapy such as metformin

It says thyroid hormones T3 and T4 directly control basal metabolic rate, thermogenesis and mitochondrial energy production, so low thyroid function reduces resting calorie burn

Cell autonomous dysfunction and insulin resistance in pancreatic cells

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However, it is important to note that many peptides remain classified as investigational