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These findings indicate that GLP-1R activation specifically inhibits GSDMD-mediated microglial pyroptosis, a finding consistently replicated in subsequent in vitro experiments (Song et al., 2022)
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However oral GSH supplementation has poor bioavailability[x] largely because it is so rapidly oxidised to GSSG as it disarms free radicals
GLP-1 innovation to-date: A duel at the top The GLP-1 market to-date has largely been a two-horse race between Novo Nordisk and Eli Lilly
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