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Major adverse limb events included any peripheral arterial disease, claudication, critical limb ischemia, endovascular therapy, peripheral bypass, and nontraumatic amputation

Bring extra ice packs or a portable cooling solution

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428 A total of 1467 AD patients were randomly assigned to receive 23 mg/d or 10 mg/d donepezil, and the results suggested that 23 mg/d donepezil significantly improved cognitive function compared with 10 mg/d donepezil

This is also linked to the production of trimethylamine-N-oxide, which in turn leads to an increased risk of atherosclerosis