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For one thing, it can interact with widely used medications

ConsumerLab.com Reveals Whats Really in Cocoa and Chocolate Products White Plains, New York, May 21, 2014 [See related new release on 8/5/14] Cocoa powders, dark chocolates, and other products made from cacao beans can be rich in flavanols -- which may help with blood flow, blood pressure, and cholesterol levels

However, no major adverse effects have been reported till now

Mol Aspects Med (2004) 25:1726

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In vivo, plasma half-life has been measured at 78 minutes suggesting that in the body, DSIP may complex with carrier proteins that protect it from rapid degradation, or exist as a component of a larger precursor molecule (whose gene and structure have not yet been identified)