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Intestinal release of GLP-1 augments initial insulin secretion in vivo in part through a vagal-vagal reflex leading to cholinergic stimulation of islet beta cells

This cascade crosstalks with the ErbB2, PI3K/Akt, and MAPK pathways, thereby circumventing trastuzumab-mediated HER2 inhibition and promoting drug resistance

J., Stemmer, K., Tang-Christensen, M., Woods, S