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A common starting point drawn from community protocols is adding 2 mL bacteriostatic water to a 5 mg vial, yielding 2,500 mcg per mL

However, in a more recent randomized, placebo-controlled study in 102 subjects, daily supplementation with 600 mg of lipoic acid (+/- 800 mg of vitamin E [-tocopherol]) for 16 weeks had no effect on fasting blood glucose, fasting blood insulin, or a measure of insulin resistance called the homeostatic model assessment of insulin resistance (HOMA-IR) index (59)

Once or twice daily

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once opened, use within 28 days

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