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One preclinical study (Valdecantos et al., ADA 2024) showed combination benefit in obese rats

I will tell you this Regev in January of 2021 I thought I was going to die

Investigations focus on molecular mechanisms, enzyme activity, pathway mapping, and assay readouts only

This is largely due to their FDA-approved indications for use in T2DM and obesity only

However, one study on the treatment of children with methylmalonic acidemia and homocystinuria found oral hydroxocobalamine at 1 mg daily to be ineffective in reducing levels of homocysteine

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