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The complexes ability to simultaneously target ROS-sensitive proteasomes, topoisomerases, and copper-dependent mitochondrial pathways creates a polypharmacological profile that disrupts multiple cancer hallmarks

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Considering the abundance of GSH in ATC cells, we developed GSH-responsive AP trapping agents with targeted anti-tumor activity

While they did not speculate on its origin since they did not examine its local synthesis, most likely they thought it was pineal-derived melatonin taken up from the blood

Below, we answer questions like: What are the potential benefits of CJC-1295