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Acknowledgements and funding The authors work on gut-derived hormones and obesity-diabetes has been generously supported over many years by Diabetes UK, Invest Northern Ireland, the Irish Endocrine Society, Northern Ireland Department for the Economy, and Ulster University Strategic Funding
Landmark trials such as SUSTAIN and STEP demonstrated significant reductions in HbA1c levels and body weight in T2DM and obesity (4, 5)
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Creatine monohydrate is the most studied sports supplement in existence
Lifestyle modifications, including reducing toxin buildup (e.g., refraining from heavily processed foods, chemicals, and substances), while consuming whole nutrient-dense foods (e.g., phytonutrients, brassica veggies, and quality proteins, including rich sources of cysteine and selenium for GSH synthesis), getting adequate sleep, movement, sunshine and circadian rhythm balance, as well as mitigating stress are all valuable tools for supporting glutathione (17-21)
This effect is achieved by reducing the expression of Trem2 and NFATc1 and downregulating the expression of CTSK and TRAP to inhibit bone resorption activity
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