When myocardial damage causes abnormalities in mitochondrial substrate utilization, oxidative phosphorylation, and a decrease in high-energy phosphate compounds, the myocardium undergoes metabolic remodeling, resulting in cardiac energy deprivation and further exacerbating myocardial damage
Nucleic Acids Res 38:48074820
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Vitamin C has been shown to reduce serum histamine levels 56, and is known to have antihistamine properties 57