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On the same presynaptic terminus of dopaminergic neurons, there are dopamine D2 receptors (D2R) serving as a presynaptic auto-inhibitory receptor, which is implicated in the regulation of DAT functions

Effects on dopamine and serotonin systems address neurotransmitter dysregulation

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However, chronic exposure leads to irreversible neuronal loss and synaptic damage, manifesting as persistent memory, executive functioning, and decision-making deficits (North et al., 2013)

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It helps orchestrate healing at the cellular level, particularly after injury