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Some medications can affect liver enzymes, and awareness of these potential interactions allows for appropriate monitoring

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While selective activation of PPAR by fibric acid derivates (fibrates) primarily improves hepatic lipid and cholesterol metabolism 3 , the selective activation of PPAR by thiazolidinediones (TZDs) enhances insulin sensitivity in peripheral tissues such as the adipose tissue, liver and skeletal muscle 4

It requires ongoing assessment based on multiple factors: weight loss progress, side effect tolerance, appetite suppression levels, and overall well-being

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