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In this context, the focus lies not on any direct peptide-to-muscle effect, but on how receptor-driven endocrine signaling remodels downstream muscle biology [6]

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Using GLP-1RAs instead of insulin cost US$54,851 and US$29,115 per case of all-cause mortality and hospitalized hypoglycemia prevented, respectively, from the payer perspective, and saved US$19,391 and US$10,293, respectively, from the healthcare sector perspective

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GLP-1RAs enhance insulin sensitivity and lower fasting insulin levels

Owing to their lack of efficacy on cardiorenal outcomes, dipeptidyl-peptidase (DPP-4) inhibitors are only recommended to control hyperglycemia