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Furthermore, studies using a peripherally administered exenatide analogue conjugated to vitamin B12, which is sterically hindered from accessing regions protected by the blood brain barrier, improves glucose control in comparable fashion to unmodified exenatide, presumably at the level of the -cell, but does not induce emesis in the house musk shrew ( Suncus murinus) or rats (78, 79)
CJC-1295 with DAC (Drug Affinity Complex) contains a maleimide-lysine side chain that covalently binds albumin in plasma, extending the half-life to approximately 6-8 days [4]
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May 2015;3(3):491-5
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