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In some patients, especially those with established retinopathy, a sharp metabolic improvement can briefly aggravate retinal findings before long-term benefit becomes clearer
It often means they have not invested in the extended stability testing required to justify longer dating
No controlled study has tested the two in combination against either alone, so combination-specific claims cannot be supported
Br J Nutr (2013) 110(7):125362.10.1017/S0007114513000597 42 Gomez-GallegoCGarcia-MantranaISalminenSColladoMC
Higher doses tend to provide the greatest weight loss and metabolic improvements, but are also associated with an increased likelihood and intensity of gastrointestinal symptoms
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