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Sources: Prkacin et al., 2001 | Sikiric et al., 1993 Stomach Lining Protection: Chronic Cytoprotection A second Prkacin et al
Semaglutide-related nausea, vomiting, and diarrhea all contribute to fluid loss
Furthermore, their differing mechanisms may complicate their effects on blood glucose and cardiovascular health
10.1021/acs.jmedchem.1c01856 23 GuoX.FengH.CaiL.ZhengJ.LiY
It is still a full agonist for all 3 receptors but it is selective for AMY1 so it is more likely to bind to this receptor while having more muted effects on the other two
In particular, compounds containing -chloroacetamide moieties have shown potent inhibitory activity
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