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FIGURE 4 5.2.2 Protecting the blood-brain barrier The BBB is a complex structure consisting of cerebral microvascular endothelial cells, endothelial cell occluding, and claudin, intercellular zonula occludens-1 (ZO-1), astrocyte terminal foot, pericyte, and basement membrane (Mark and Davis, 2002
It does not provide instructions for human use, dosing, administration, veterinary use, or any non-research application
In 2014, the FDA approved the first of these drugs specifically for weight loss for people with a BMI of 30 and above or a BMI of at least 27 with one weight-related comorbid disease, which affects more than half the U.S
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J Inorg Biochem 195:111
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