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robust human dose-finding data remain limited

Maintenance Dose (Week 13+): 12 mg The 12 mg dose produced the highest weight loss in every trial: 24.2% at 48 weeks (Phase 2) and 28.7% at 68 weeks (Phase 3 TRIUMPH-4)

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Retatrutide may be more suitable for patients who can tolerate initial gastrointestinal side effects in exchange for potentially greater weight loss efficacy, but cardiovascular monitoring may be required