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Tapering may be helpful if using long term (6+ weeks), but isnt physiologically necessary

"[It] has better absorption and is more likely to survive the enzymes in the gut that break it down and prevent absorption," said Lee

In particular, for the parallel design studies (treated versus untreated patients or different treatments), the small sample sizes could have led to ineffective randomization and potential confounding, while in longitudinal (non controlled) trials it is difficult to draw any firm conclusion

RostovtsevaTKQueralt-MartnMRosencransWMBezrukovSM

M.de VriesH

Statistical analysis Statistical analysis was performed with SPSS 21.0 for Windows (IBM, Armonk, NY, USA)