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5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT)a metabolic regulator tied to fat storage, NAD depletion, and reduced energy expenditure

For each eligible study, two authors (MM and AN) independently extracted data, which was then reviewed by a third author (JV) using a piloted spreadsheet, in accordance with Cochrane Collaboration guidelines ( Where relevant data were missing, attempts were made to contact corresponding authors

MOTS-c is also being studied for longevity (life extension) due to its role in cellular stress responses

Healthy red blood cell formation

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Patients with mild, recently developed deficiency typically respond more rapidly than those who have been deficient for months or years