At a further level of complexity, many nanoplatforms are also engineered to interact with defined immune cell populations or signaling pathways, with the aim of partially relieving immunosuppressive features of the tumor microenvironment and creating conditions more permissive for systemic immunotherapy or rational combination regimens [9, 29, 35]
The development of GLP-/GIP dual agonists provides a more complete scheme for the treatment of metabolic diseases, but the safety of more dual agonists or multiple agonists in clinical trials is also worthy of attention
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