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JAMA 331 , 16721673 (2024)

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Increased iron in brain tissue causes reactive oxygen species (ROS) formation via Fenton reaction, inducing ferroptosis and finally leading to neurodegeneration (Kim et al., 2015

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"GLP-1 probiotics" is a marketing term (not recognized by the FDA) for dietary supplements promoted as natural alternatives to prescription medications like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound)

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Stoichiometry is a separate measurement from purity and requires an orthogonal method such as atomic absorption or ICP-MS

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Results Anti-nitrative effect of trisulfides as an introductory part of the study Given the potent anti-oxidative functions of GSSSG and LASSS, the first set of experiments was designed to examine if these trisulfides have potential to prevent peroxynitrite-induced nitration-dysfunction of HGF by ECL-Western blotting (see Figure 1a for the in vitro experimental design)

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