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The titration regimen described in the NEJM 2023 obesity trial (Jastreboff et al.) progressed as follows: Weeks 14 : 2 mg once weekly Weeks 58 : 4 mg once weekly Weeks 912 : 8 mg once weekly Week 12 onwards : Up to 12 mg once weekly (in higher-dose cohorts) This regimen was used exclusively within a regulated clinical trial setting and does not constitute an approved dosing schedule
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In practice, only 1013% of patients reach maximum doses
Helps improve firmness and elasticity
If constipation persists beyond 8 weeks despite lifestyle changes, contact your PlexusDx provider to discuss potential adjustments to your treatment plan or alternative compounds like tirzepatide
High IR leads to more noticeable voltage drop as you increase throttle, a phenomenon known as voltage sag
