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Second, the terms glucagon-like peptide-1 receptor agonist and sodium glucose cotransporter 2 inhibitor (including exenatide, lixisenatide, albiglutide, dulaglutide, liraglutide, semaglutide, taspoglutide, canagliflozin, dapagliflozin, empagliflozin, ertugliflozin, ipragliflozin) were searched in PubMed, CENTRAL, ClinicalTrials.gov, EudraCT, Scopus and Web of Science
A central therapeutic action of GLP-1 RAs in NASH is the improvement of insulin sensitivity in both hepatic and adipose tissues
These findings suggest that spinal afferents also seem to play a major role in mediating the effects of GLP-1R agonists on energy balance
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